I haven't but I'm planning a new site and I'm going to give it a go. I have a site with entities rather than just pages, so the content model seems to fit. I used Django-CMS about 4 years ago and it didn't support the people editing the site in terms of UX. So I ditched it and went with Wordpress (which I'm not happy with, hence wanting to change).

I used to work for Torchbox who are developing Wagtail, so I heard about it before it went public. But looking at the uptake on http://madewithwagtail.org/ it seems to be doing very well in the market.