Metformin as a Geroprotector (2011)

Re:Metformin as a Geroprotector (2011) by gliese1337 on Tuesday December 08, 2015 @11:56AM (#10697609)

My wife was recently on metformin for a while. According to her, even if metformin does prevent aging in humans (which is not at all certain), it would not be worth the side effects.

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Re:Metformin as a Geroprotector (2011) by DennisP on Tuesday December 08, 2015 @12:05PM (#10697684)

Some people tolerate it pretty well, others don't. The gastrointestinal effects usually lessen after a while.

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Re:Metformin as a Geroprotector (2011) by DrScump on Tuesday December 08, 2015 @07:34PM (#10700982)

Gastrointestinal upset can be mitigated by always combining with food and spreading out among smaller doses.

If she was prescribed 1g tablets, for example, have her ask for a new script for twice as many 500mg tablets. (Those 1g are a pain to split.)

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Re:Metformin as a Geroprotector (2011) by stahlkopf on Tuesday December 08, 2015 @03:30PM (#10699239)

What side effects specifically?

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Re:Metformin as a Geroprotector (2011) by gliese1337 on Tuesday December 08, 2015 @10:18PM (#10701696)

There is a fairly wide range of possible side effects, none of which are terribly pleasant, though I don't know how relatively common each of them is.

In my wife's case, it was nausea and hypoglycemia.

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