I'll trust his numbers. But is 20-100% enough to say "targeting works"?
And yes, targeting works. But non-animated banner ads also used to work, and they worked even better than quite a few targeted campaigns do today (hence the shift to performance based advertising rather than CPM and CPC campaigns, they are also much more resilient against fraud but much harder to properly set up).
There's an exception: Targeting geographical areas obviously works. If your market is the city of Toulouse, targeting by geoip gives you most of the intended audience and eliminates almost everyone else, at low cost.
The rest of the targeting techniques? Trying to pick male users, trying to pick users over 50 or between 20 and 30, trying to pick people who've visited faucet FAQs in the past? There's a long-term strategic cost in user revulsion and there's an immediate technical cost in implementing the tracking.
I won't try to put a number to the cost of creeping out users and making them install adblock, ghostery etc, but it does not seem safe to assume that the cost is smaller than the value of those 20-100% additional clicks.
(a) On HN, it doesn't match the ideological overtones so it won't be voted up.
(b) In general, it's not interesting. Most business owners already know that advertising works and aren't terribly interested in hearing the obvious.