>Same thing with natural plant vs chemical extracts. Much easier to overdose and get lethal dosage.

One point of contention I'll raise is that with self-grown anything one can control what adulterants are added.

A particular problem with opioid overdose is the tendency for opioid pain killers to have paracetamol/acetaminophen/APAP/Tylenol added, which when taken in large doses will cause permanent liver damage.