Re:Scientists identify main component of brain repair after ...
by ezequiel-garzon on Saturday October 31, 2015 @09:25PM
(#10485030)
Has she made progress with this therapy? I'd heartily appreciate as much commentary as possible. My mother also had a stroke many years ago. Best wishes.
Re:Scientists identify main component of brain repair after ...
by markkat on Sunday November 01, 2015 @12:51AM
(#10485453)
Why is this of particular interest? I work in a neurology research lab that specializes in stroke. There are dozens of proteins that have similar effects, BDNF, EGF, VEGF, NGF, etc., not to mention miRNAs.
This is just one small component of brain repair.
Oddly, it seems that I am seeing more of this on HN lately.
Re:Scientists identify main component of brain repair after ...
by agumonkey on Sunday November 01, 2015 @10:55PM
(#10489917)
How early does these trigger growth ? I find it a bit paradoxical that in a time of resource denial growth should occur. Obviously I'm missing something.
Re:Scientists identify main component of brain repair after ...
by nonbel on Saturday October 31, 2015 @09:23PM
(#10485028)
>“We found that GDF10 caused many different neurons in a dish to grow, including human neurons that were derived from stem cells,” said Dr. Carmichael.
NGF (Nerve Growth Factor) is added to dishes nearly every time such experiments are done to get neurons to grow. I'm sure they plated them on laminin or whatever substrate works best for those neurons as well. I haven't read the paper, but from the layman's description this sounds like hype.
Re:Scientists identify main component of brain repair after ...
by waltherp on Sunday November 01, 2015 @01:30AM
(#10485541)
Im not sure if this is a new find. Doctors in Japan and Karolinska Institutet in sweden did something similar when they took samples from patients who received cord cell transplants. The findings suggested suggested that brain function can be improved using mesenchymal cells that secrete growth factors and cytokines which activate a mechanism that leads to improved neuro function,neurogenesis and angiogenesis. The issue is that the results should be able to be verified with long-term follow ups to evaluate functional outcomes and possible harmful effects.
This work was supported by grants from the NINDS (NS085019, NS086431) and the American Heart Association (09SDG2310180).
This is just one small component of brain repair.
Oddly, it seems that I am seeing more of this on HN lately.
Link to pdf: http://www.nature.com.sci-hub.club/neuro/journal/vaop/ncurre...
NGF (Nerve Growth Factor) is added to dishes nearly every time such experiments are done to get neurons to grow. I'm sure they plated them on laminin or whatever substrate works best for those neurons as well. I haven't read the paper, but from the layman's description this sounds like hype.
http://www.ncbi.nlm.nih.gov/pubmed/11988611
https://clinicaltrials.gov/ct2/results?term=stem+cells+AND+s...
http://stemcellthailand.org/therapies/stroke-ischemic-hemorr...