Re:When sequencing makes genotyping obsolete (soon)
by biomcgary on Friday October 23, 2015 @12:47PM
(#10439741)
For a few years, DNA sequencing significantly outpaced Moore's law. Then, Illumina beat the competition so badly that they folded.
Re:When sequencing makes genotyping obsolete (soon)
by waiquoo on Friday October 23, 2015 @01:01PM
(#10439831)
I've got something for nanopore sequencing coming out in the next few month. Stay tuned.
Re:When sequencing makes genotyping obsolete (soon)
by adenadel on Friday October 23, 2015 @02:16PM
(#10440321)
Do you use a different nanopore than α-hemolysin or MspA?
Nanopores are no where near the throughput and accuracy of Illumina's sequencing by synthesis tech, and if there is a pathway to challenge Illumina's position, it will be extremely complex, iterative and _long_.
Meanwhile Illumina is amassing a billion dollar war chest and is adding its own complex and iterative improvements to its platform (two-color detection, longer and longer reads, higher cluster density), maintaining its market lead.
As much as the analogy to microprocessor manufacturing and Moore's law is alluring, the messy stuff of biology and single molecule chemical manipulation and sensor detection is unlikely to obediently follow the same innovation curve.