"every mouthful of food you and I have ever taken contained many billions of kinds of complex molecules whose structure and physiological effects have never been determined—and many millions of which would be toxic or fatal in large doses. We cannot doubt that we are daily ingesting thousands of substances that are far more dangerous than saccharin—but in amounts that are safe, because they are far below the various thresholds of toxicity. But at present there is hardly any substance except some common drugs, for which we actually know the threshold."

E. T. Jaynes