Yes, but it is much easier to do them responsibly if you have other rewarding activities to look forward to.

I, for example, spent almost six months high a couple of years ago and loved it. I stopped because the hippies I was working for ran out of money. I was about an inch away from homelessness before I managed to get a job as a software developer. I was sober at work, but I'd get fucked up as soon as I got home, later with friends, &c. Now that I'm working on my own startup my drug usage has declined even more. I still get high when I have the chance, but I have other highly stimulating activities to spend my time on now.

I wouldn't recommend my life choices to anyone else, but there are ways to responsibly partake of excess.