For anybody who studies science that isn't an uncomfortable question and it's over century old at this point. The last time the field of science had a high level of certainty that it would solve everything ever was probably the late 1800's.

I dealt with this question in high school physics, it's really no big deal. When you get to a point where all you can do is make a "metaphysical claim with no greater merit than its opposite" you go find something better to do with your time.