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Re:El Capitan and Homebrew by omribahumi on Thursday October 01, 2015 @10:14AM (#10311273)
It is possible to switch /usr/local according to [1], they state it's not recommended though.

[1] https://github.com/Homebrew/homebrew/blob/master/share/doc/h...

Re:El Capitan and Homebrew by halostatue on Thursday October 01, 2015 @11:09AM (#10311658)
I have used ~/.brew for years—it means that I have to do a slightly custom install every time I move to a new machine—but have never had a problem with it.