The screen kinda has to be made of glass, and even Dow Corning's finest will break if it hits a hard surface. I believe synthetic sapphire is available for watches and smartwatches but not for any actual phones?
Best solution is a case with rubberised corners.
Extending the bezel to the edge of the phone means there's no "crumple zone" to absorb energy of impacts - that shock goes to the screen.
Personally I think a mobile phone that looks lovely but has little chance of surviving metre drop is a design fail.
Modern phones are stupidly flimsy.
That was also the big era of replaceable phone cases. I think people who are worried about the frailty of the phone buy secondary-market protective cases these days.
I just checked -- the 2nd gen model Moto G is $149.99 on the Motorola website (free shipping). Add a few bucks of tax and it's still one third the price of these other offerings. MicroSD slot, water resistant, 5" display, pure Android experience. This is what the Nexus should have been. Except unfortunately it lacks NFC, ditto the 2015 model.
If it had NFC I'd consider getting one myself, but unfortunately that's a showstopper for me -- I write NFC apps for a living.
If Moto would put NFC in this bad boy, they'd have a killer phone!
Now, the Moto X for $400 does have NFC - plus a microSD slot. Hmmm.
$499 for a decent 6 inch phone seems like the real story here. Especially if it gets the typical Nexus price cut 6-9 months out. $449 or $399 for this could happen sooner than later, which would be an amazing deal. $499 is still really good, considering the previous N6 launched at $650. I'm surprised Samsung didn't balk at this, its pretty much a shot at their Note line which typically sells for $600+ unsubsidized. I think Google is trying hard to make phablets happen for non-techies any way they can, even to the point of pissing off their biggest OEM's. I also suspect there's some politicking here as Google is trying to groom Huawei to go after Samsung's massive marketshare. Samsung being the defacto Android product isn't good for Google or Android.