I toured Chattanooga the other day. It's a cute town, but it felt kind of small and somewhat empty to me. I lived in Atlanta for 4 years during my undergrad. Despite being only 30 minutes away from my immediate family, Atlanta is one of my least favorite cities in the US. Too much crime, too little ambition (at least compared to SF and NY), horrible traffic, and not much "living" going on within the city. Everyone basically commutes into it from the suburbs for work and then drives back out in the evening. If you wander around SF, you see all kinds of people out and about. In Atlanta, everyone's cooped up inside; the sidewalks are mostly empty.
Raleigh, Cary, and Charlotte are nice, but they're a little too suburban/vanilla for my taste.
Nashville is quickly becoming my top choice (if I'm unable to live in San Francisco or Austin, TX). I have some family there, and I recently read that it's one of the fastest growing cities for 25-30 year olds interesting in technology.
So, I don't know... as someone who's lived here almost all my life, I just wish the South had at least one big city that was world class in something.
Google (Chapel Hill -- small engineering office mostly used to recruit interns from UNC & Duke)
Citrix (downtown Raleigh -- I think this is their biggest office outside Santa Clara, and they consistently have 50-75 job openings there)
NetApp, Microsoft, Lenovo (their HQ), IBM (still a major presence even though it's shrunk a lot over the past decade), Genband/Avaya/Ciena (all created after Nortel's implosion), BASF, Bayer CropScience, SAS (HQ), John Deere, Credit Suisse, Cree (HQ), EMC, Fidelity Investments, RTI International, the US EPA, and many more.
In biotech, there's, Pfizer, Biogen, Merck, UCB Biosciences, Quintiles, Parexel, PPD, United Therapeutics, Glaxo SmithKline, Syngenta, and many, many more pharmas & CROs.
[0] Not even to pass through on the periodic AL<->PA trips I used to take!
Also, Charlotte. It's like Atlanta, but better/smaller/in the foothills of NC. So like Atlanta, but better.
* Nashville, TN
* Atlanta, GA (Assuming that I still possess enough of my tech "fortune" to purchase a place inside city limits.)
* Chattanooga, TN (For EPB internet and what appears to be sensible city stewardship, obviously.)