There was a SF author (Bear or Brin?) who wrote an essay back in the 90's about the future of drug wars. Much of the enforcement back then was on stopping the import of drugs from overseas. But once gene splicing created a way to produce the drugs within the USA, the enforce would switch to raiding warehouses, etc. The next step would be when the technology reduced the drug manufacture to a table top box that could be in any home (think make your own insulin). Then the enforcement has to raid peoples homes. The last step is when the technology allows the drugs to be produced by symbionts growing within a person.