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Re:Peter Thiel Explains Biotech Investing Rationale: Get Rid... by eli_gottlieb on Monday September 14, 2015 @09:12AM (#10214860)
It's basically just thermodynamics: if you're willing to spend enough energy, you can optimize the state an arbitrarily large system as you please.

Of course, the key words there are enough energy. It sounds like Thiel might be forgetting to account for what we want to optimize and how much effort we're willing to spend on it.

Re:Peter Thiel Explains Biotech Investing Rationale: Get Rid... by HiYaBarbie on Monday September 14, 2015 @10:14AM (#10215134)
> if you're willing to spend enough energy, you can optimize the state an arbitrarily large system as you please

Define "optimize" and "system"?

Re:Peter Thiel Explains Biotech Investing Rationale: Get Rid... by eli_gottlieb on Monday September 14, 2015 @04:34PM (#10217301)
"System" -- any bloody thing you care about, any collection of mass and energy.

"Optimize" -- to constrain the system to within a subset of its state-space. Or in other words, to make only some things happen rather than all other possible things.

Generally, as long as something is physically possible, you can spend some amount of energy to make it reasonably probable or unreasonably improbable. This may just be far more energy than you happen to have, or care to spend.

Re:Peter Thiel Explains Biotech Investing Rationale: Get Rid... by HiYaBarbie on Monday September 14, 2015 @10:51PM (#10218731)
So how does the 'optimization' work? :)

I have no clue about physics, so I'm just curious.

Re:Peter Thiel Explains Biotech Investing Rationale: Get Rid... by eli_gottlieb on Monday September 14, 2015 @10:56PM (#10218742)
It doesn't. It's really a deliberately vague term referring to any physical action designed to put the system in one state rather than another. A thermodynamically non-reversible action, you could say.
Re:Peter Thiel Explains Biotech Investing Rationale: Get Rid... by HiYaBarbie on Tuesday September 15, 2015 @12:19AM (#10218927)
Alright. Well, we're talking about something that might be theoretically possible, but is impossible in practice. I don't think it matters.