AFAIK, Romans built their cities with streets following the N-S and E-W axes (Cardus and Decumanus) but, after, no medieval city continued with this style. Specially, in walled cities, the streets were appearing in a chaotic way.

My home city is Barcelona where, actually, a big part is designed as an orthogonal grid.... but it's still not the same. I think I would have enjoyed the game more if I knew how my cities were supposed to look like.