After experiencing wrist and back pain, I found it helpful to rotate my setup between desktop and laptop. At the office, I use a relatively ergonomic desktop setup with a keyboard draw and a 24" monitor at eye-level. If I need to work during the evening, I use a folding wood laptop table in bed (allows adjusting the laptop to proper angle) or I sit on a recliner that keeps my hands and eyes at the proper angle. I try to avoid using a laptop on a standard desk whenever possible.