Is ketamine the best hope for curing major depression?

Re:Is ketamine the best hope for curing major depression? by zastavka on Wednesday August 19, 2015 @02:21PM (#10087411)

To be fair, the dosages most of these doctors are administering are well under a usual recreational dose, as the article mentions. IIRC you also build tolerance to ketamine pretty quickly, so I'd imagine the amount of K those people are doing that's causing bladder damage is a couple orders of magnitude larger than any of these patients.

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Re:Is ketamine the best hope for curing major depression? by user_0001 on Wednesday August 19, 2015 @02:45PM (#10087582)

You don't get bladder problems using / abusing ketamine just at weekends.

People sniffing it every day / all day and getting through the 5grams+

But hammering that much every day of any drug is not a good idea.

At the above+1 commenter, take LSD at high doses everyday and see what damage you do to yourself

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Re:Is ketamine the best hope for curing major depression? by scarmig on Wednesday August 19, 2015 @03:55PM (#10088026)

LSD is as close to as harmless a drug, physiologically, as you can get--no one has ever died of an overdose on it, and there isn't permanent physiological damage that happens even with regular heavy use.

Of course, your psyche might be another matter...

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Re:Is ketamine the best hope for curing major depression? by user_0001 on Wednesday August 19, 2015 @08:07PM (#10089348)

Agreed, not physically damaging. But it can destroy you mentally if used often and in heavy doses.

>but I've never heard of LSD destroying a persons bladder. That was the quote I was referring to. Bladder in tact, but a shell of a person left with severe paranoia and mental problems.

Not to hate on LSD, but no drug is safe is abused daily.

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Re:Is ketamine the best hope for curing major depression? by ionised on Thursday August 20, 2015 @05:19AM (#10090726)

I'm not sure it's even possible to do decent quantities of LSD daily, at least in the context of trying to achieve a potent effect.

Plenty of times in my life I've done LSD and I learned pretty early on that it was pointless to try a dose the day after a previous dose.

It would just have very little to no effect on my mind and I would typically have to wait a few days at least before doing it again before it worked.

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