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Re:Brains Sweep Themselves Clean of Toxins During Sleep (2013) by Jun8 on Friday August 14, 2015 @05:13PM (#10062980)
This source (http://udel.edu/~danikoll/metabolism.html) validates your point that caffeine has an indirect rather than direct effect on cAMP:

"Caffeine competitively inhibits phosphodiesterase, the enzyme that degrades cyclic AMP...By blocking the degradation process of cyclic AMP, caffeine indirectly affects regulation of cAMP-dependent protein kinases". TIL.

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