Some of the gatekeepers of the peer review systems have had a long and celebrated history here, and sometimes to the detriment of the purpose of the review process.

The experiences of John Harrison and the Board of Longitude and the Royal Society, or the initial reception of the work of Barry J. Marshall and Robin Warren around H. Pylori, both come to mind.

Most any large shift can involve overcoming very strongly-held beliefs; of sticking your neck out.