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throwme431

> Long COVID-like symptoms or not, the protection afforded by COVID vaccines still clearly outweighs the negatives.

I don't think it's that simple to make such a blanket statement anymore. In much/most of the developed world, over half the population has already received 2 doses of vaccine and the conversation is moving from "What about the people who choose to remain unvaccinated?" to "Are you fully vaccinated with just 2 doses?" and "How many boosters do we give and how frequently do we give them?" We've gone from thinking that we might need a booster a year to advising people to get boosters just months after a previous jab.

In light of omicron, the cost/benefit analysis is not anywhere near as clear anymore, especially when it comes to these boosters. There's also the issue that risk varies by magnitudes of order between age and comorbidity risk groups, and overall risk of severe outcomes is lower for all groups with omicron.

From the article:

> She says she has preliminary evidence that vaccination can lead to microclots, although in most cases they go unnoticed and quickly disappear—an effect she and a colleague saw in their own blood and that of eight other healthy volunteers, which they sampled after their vaccinations.

This highlights the fact that there's a ton we still don't know. What if there are subclinical effects of vaccination that have the potential to affect people's health in negative ways, either in the near term or long term? Even small changes in uncommonly tested biomarkers can be clinically meaningful over longer time periods.

Perhaps it's reasonable to argue that made the right decision early on by accepting these unknown risks in light of the efficacy of the vaccines at preventing hospitalization and death pre-omicron. But is it reasonable to do that with never-ending boosters when the currently dominant strain is proving to be far less virulent in all groups? Is it still reasonable to push for vaccination and boosting of children and younger and middle-aged adults who are otherwise healthy and at significantly less risk than older, unhealthy groups?

If we just blindly accept that the cost/benefit analysis of vaccination always favors vaccination, how would we ever know that we've crossed a line where that is no longer the case?