throwaway6111

They're also just doing analysis on a static data set.

> PED was determined by manual review of medical narratives for all subjects with ED. Risk of an adverse effect was expressed as number needed to harm (NNH).

So this doesn't rule out the possibility of the subjects' mental state affecting their ED.

0.8% of a 4000+ sample size had PED with the regular dosage for baldness treatment. That's absurdly low and pretty much confirms that though the risk is there, it's highly unlikely. Its even more ridiculous that 1.4% of the ENTIRE sample size (over 11,000 people) taking less than or equal to 1.25mg of fin, greater than 1.25mg of fin, and dutasteride reported persistent ED.

As a fin user I actually find this data to be re-assuring.

I'm a fin user and frankly I'm surprised to see this here. It's already well known that persistent ED is a potential side. I'm guessing its here because its a new study and other HN readers are curious about the drug (or taking it).

> Among men 16–42 years old and exposed to finasteride ≤1.25 mg/day, 34 of 4,284 (0.8%) developed PED (persistence median 1,534 days, IQR 651–2,351 days); the multivariable model predicting PED had one variable: duration of 5α-RI exposure

So less than 1% of finasteride users get PED. PED was already a known side effect. That's good it's being confirmed with data, but aren't the odds still very low that this would happen to fin users? As a fin user myself, I haven't experienced any of the sexual sides so I'm wondering if there's any new take-away from this.

When I look at this as a fin user, I'm personally happy to see that the data says its so unlikely.