suryong

You are basically meant to prop up the pension ponzi-scheme because they are running out of payers and the amount the boomers paid was quite little relative to now

Same in Finland, the employer side constantly screaming about worker shortage, but I have been in several interviews where when I presented my salary request, I could see the person grin because they thought it is too high but it was just little higher than my current... Luckily, I got a new job in Hong Kong with decent salary and lower tax rate.

They want to saturate the market with massive immigration so the salaries never rise, but when there are too many developers, they can actually push them down. If there would be real shortage, they would increase the salary.

Here in Finland they are screaming WORKER SHORTAGE too, but when you talk about salary, suddenly there is no shortage. It's interesting view of the market that when there is a shortage, they should be able to import more and more workers from the outside so they don't have to increase the salaries, but when there is less demand, the salaries should also go down. By this logic they should never increase

I have played for over 30 hours since release, and now at Act 2. It's one of the best games I have played. I am not a huge D&D fan, but I like real RPG games where the player choice actually matters such as DOS 2 and Pathfinder WOTR, so this one was instant buy for me and I am very pleasantly surprised. I can already see myself doing another playthrough, there is lots of diverging in the story. Too many so called RPG games nowadays are just pipes that you walk through with some kind of illusion of choice and few lines of different dialogue.

The inventory management is little messy and could be better, but honestly I don't find much else to critique yet.

Because it is actually an RPG, there is actually choices there, even in Act 1 there are quite few major choices that have big ramifications in Act 2. Take something like Pillars of Eternity, it mostly had the illusion of choice and not much real reactivity, the npcs might say few different lines but it really did not matter much.

I am tired of the games that present you with illusion of choice but it actually doesn't matter. In BG3 you can actually be the evil character so that by itself lends the game at least for 2 playthroughs. Personally I am playing it through as Dark Urge first, and later going to do another run with good druid.

Also the graphics are really nice, almost everything is voice acted, companions have interesting stories. Story is already much better than divinity 2. I have 39 hours in now and I bought it at launch

There are places like HK and Singapore where firing is super easy, yet the software industry in those places still pales to USA and even to Europe in some cases

The org I work at has the same issue with Elm, there is one Elm product and no one really wants to take those tickets because everyone hates dealing with it. It has become a total pain in the ass, and I believe someone is rewriting the app in React

Of course we cannot be 100 % sure it will work for humans, but the results on mice are promising and they are replicated by different labs which is very rare for anti-aging compounds. Rapamycin consistently shows effect. The effect on humans probably won't be anywhere near the 25% increase that is shown on mice, we will maybe get some extra years + better health span but the cumulative effect on society will probably be more than any current intervention. If we look at how ageing appears on different mammals, it is actually remarkably similar in terms of the decline, the speed is just different so I would say it is indeed quite promising if the mice results are replicated majority of times.

There was study on a drug what is now called Everolimus (mTOR inhibitor) and it showed that it increases the influenza vaccine effectiveness on elderly people https://pubmed.ncbi.nlm.nih.gov/25540326/

The dog aging study is ongoing and they are conducting double-blind placebo controlled trial for rapamycin on dogs. https://newsroom.uw.edu/news/tech-entrepreneurs-pledge-25-mi...

Some smaller scale study on rapamycin for dogs: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411365/

I just don't think there is any compound currently that is more promising than rapamycin, so that's why I mentioned it here.

The most promising future treatment seems to do with cellular reprogramming as it increasingly looks like epigenetic alterations are responsible for a large part of aging, the epigenetic drift theory of aging. https://www.nature.com/articles/s41580-019-0204-5

Good video about epigenetic drift theory by Vera Gorbunova from University of Rochester. https://youtu.be/FhfXP_MX0U4?t=639

The current way of doing medicine for the elderly will never work simply because of ageing, it is like trying to bail water from a sinking ship without fixing the hole. Will work for a short while until it doesn't. I am also very skeptical of getting a working treatment for diseases like Alzheimer's disease without intervening in ageing.

Already when I was a teenager I realized that treating ageing is the holy grail of medicine and it seems recently this field is gaining more attention, but realistically it will be decades in minimum until we get some more radical treatments, might be even longer. At least the billionaires have realized that there is not much point being a billionaire if your body is breaking apart.

All we have now is lifestyle choices, possibly some medicine like rapamycin, and just hoping we don't get unlucky. Worrying trend is also people taking HGH for anti-aging but in the lab it seems to have complete opposite effect, it actually seems more like ageing accelerator.

What we really need is robust treatments that either slow down the ageing process or reverse it to some extent. There is some promising research relating to both slowing and reversing. The current approach where we treat age related disease as individual things will never really work out in the long term

One thing right now that is available is rapamycin which basically improves health span and lifespan for every animal it is given, won't make you live to 150 but will probably reduce risk of disease.

I am considering starting rapamycin myself as my mom was diagnosed with ALS few months ago (doesn't seem strictly genetic as her mom and dad lived relatively long and didn't get that disease), so I might have some risk genes..

World where people live to 90-100 and where increasing amount have dementia or other age related disease won't be a nice place