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miasma

Yes, It has had Linux support since late 2009; I've been playing it regularly without issue on my Linux box ever since.
Re:Valve Source Engine Running Faster on Linux than Windows on Thursday August 02, 2012 @12:09PM (#4329396)
In my experience Linux mouse acceleration is actually more customisable than in Windows; X11 has several related options that can be added to your xorg.conf or changed without restarting X with xinput.

http://www.x.org/wiki/Development/Documentation/PointerAccel... has a good rundown of all the options, perhaps the most important being the "Acceleration Profile", which can be set to -1 to disable acceleration.

As for firmware related acceleration, I've not ran into any - but I can certainly imagine this being something easier to manage under Windows, considering practically all "gaming" mice are aimed at Windows users.