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meatyloafy

They were killed by what the settlers brought with them. No, it was not deliberate (#), but nevertheless, their arrival is what killed most of the natives.

(#) Obviously the settlers would have preferred to keep the natives alive since then they would not have needed to ship vast quantities of Africans across the ocean to enslave, but could have just done that with the locals.

All except the last.
Anybody dreaming of Mars colonies should keep that in mind. As long as the Mars colony will be dependent on supplies from Earth, they will do what Earth wants. Once they are self sufficient, this will change.

C.f. the immigration-friendly early U.S. and its "close borders" and PR lottery approaches of today.

There is quite a difference between conquering (and thereby assimilating) versus killing almost all natives and then populating the place with your own settlers..