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Re:OpenSpec – A lightweight and configurable AI spec framework on Thursday September 17, 2026 @09:44AM (#49740663)
Hi, your comment motivated me to try it out on my project. I'm looking for some advice.

I had a 2000 line specification, but no code yet. Based on lat.md, I have split the specification into 25 different files in the lat.md folder (not sure if that's too many).

My next task is to create a staged implementation plan, but I'm not sure how lat.md can help me (or is it even designed to?). Should the implementation plan stages also be separate markdown files in the lat.md folder? Or a sub folder? (Does it matter).

My understanding is that lat will help create a knowledge graph between the specification files the implementation files, and the code.

Re:Ask HN: What are you working on? (September 2026) on Tuesday September 15, 2026 @04:35AM (#49709498)
I am building a Pump.Fun/Solana trading bot for ultra-shit coins... because I have identified a edge that lets me exploit the 'bonding curve' in Pump. I've "won" using this strategy manually, now I want to automate it. I am also this an example for learning spec-driven development (i.e. iterate the spec in Claude Code, using adversarial models).

My challenges are: The Spec has ballooned to 2.5k lines, and I dont know how to "split" it up for coding/implementation.

Re:Some Things Just Take Time on Saturday March 21, 2026 @06:32PM (#47472220)
shouldnt it be the other way around?
Re:How to sequence your DNA for <$2k on Sunday October 19, 2025 @06:44AM (#45633337)
These guys didn't do their homework correctly. Keeping aside commercial vendors; their own garage setup for doomed to fail with their coverage (or lack thereof). Garbage in, garbage out.
Re:Pfeilstorch on Saturday August 16, 2025 @02:17PM (#44925720)
I "smell" a bias there. Keep your politics out please.
Re:Ask HN: What are you working on? (March 2025) on Monday March 31, 2025 @01:56AM (#43531573)
Seems useful, why isn't this more popular?
I would urge you to watch a statistical debunking of these so-called "global goodness" metrics. Sanjeev Sanyal does a good job of it [1],[2],[3] Multiple organization(s) that manage such indices are, turns out, funded by the same cabal who want to concoct a narrative. They are not unbiased.

[1] https://www.youtube.com/watch?v=3Lgf2WHstBY

[2] [PDF] https://eacpm.gov.in/wp-content/uploads/2023/03/Reversing-Ga...

[3] https://www.businesstoday.in/india/story/sanjeev-sanyal-blas...

Re:Disney Layoffs 7000 People on Monday March 27, 2023 @04:34PM (#35332122)
go woke, go broke
The fugitive is the leader of the Khalistan-independance movement, eventho the majority lies in Pakistan. Yet, they want to secede from India. There are numerous reports he's terrorist being financed by Pakistan. I hope India adopts doesn't go easy on these terrorists.
Re:The Vindication of Ask Jeeves on Wednesday March 08, 2023 @03:59PM (#35074637)
HotBot represent!
While we are at it, a small shout-out to PDF X-Change Viewer/Editor. Best part for me is that it works on Linux (via Wine) and Windows.
Re:I made an early 2000s-inspired internet forum on Thursday February 16, 2023 @08:34PM (#34829498)
Didn't think I'd see EJ mentioned here. I distinctly recall planning and reading raiding strategies in there fur hours. I think there largest Onyxia thread was started by me. Glorious times.
I saw the video the day it came out. Its an OK video, but I question the timing in wake of the upcoming elections and Modi leading the G20. Typically I call out "rejection manipulation" or "external interference", but I'm increasingly starting to suspect the intentions of the BBC (and other media)

The metrics you mention are not poor, but our data is poor. Furthermore, numerous research shows HDI and GDP are flawed (but legacy) metrics - this is exasperated by the poor quality data available in a chaotic country like India

There is a sampling bias at play right here in HN with the Modi-bashing comments. Indians, and India, is doing great overall. Modi's leadership has played a big role in this. Indians are (generally) emotionally people, and by no means is it an authoritarian state. In fact, we need wise leaders with vision to manage this population.
Re:Tell HN: Confluent laying off 8% of staff on Thursday January 26, 2023 @11:02AM (#34533454)
I am not joining this pity-party.

Companies hire tech workers to stifle their competition; whilst keeping their workers 'sedated' on fake projects (i.e. projects that are paraded as important, but the 'inner-circle' knows well its just to keep the nerds happy). During tough times, its not unreasonable for a company to trim their fat. Personally, tech and academia has been bloated for over a decade now. So no foul here.

Re:Advanced Scientific Data Format on Wednesday October 05, 2022 @04:33AM (#33092808)
FASTQ is not for Excel, obviously - although you can still explore it in the shell. Nonetheless operating directly on FASTA/FASTQ files is often a "one-time" preprocessing task. You then serialize the preprocessed data and continue on from there.

FASTA (and its various incantations) are not going anywhere anytime soon.

Re:Advanced Scientific Data Format on Wednesday October 05, 2022 @02:42AM (#33092077)
The "bioinformatics formats" might be terrible, but they work. In fact, they are meant to be Excel-readable which keeps my collaborators (and me) happy. Coming from a CS /programming background, it is natural to feel the urge to "fix" the formats (<insert relevant XKCD>), until you realise that there are a libraries that easily handle serialization/parsing.

Besides, "bioinformatic formats" is a meaningless word anyway. FASTQ, VCFs, BCL, AIRR-seq -- all different and it just works.

Re:Ask HN: How to Stop Caring (Professionally)? on Sunday October 02, 2022 @08:09AM (#33055209)
I will bite. I dont think you care as much as you claim (or think) you do. Its likely you are not respected amongst your peers (for whatever reason) and you feel alienated. I've seen too many employees cite "lack of autonomy" because they want re-write code in Julia (for example) instead of prioritizing tasks they were hired to do. They think management doesn't "get it".

> But my personality finds it difficult to ignore things that are wrong

That's what you think. Maybe you are a man-child throwing a tantrum? The tech world is filled with such folks.

Even if everything you said is accurate, you will be happier if you dont play the victim card.

Re:Want cleaner code? Use the rule of six on Saturday September 24, 2022 @01:15PM (#32964614)
Early in my career, I took to heart such books and articles and often felt guilty and lessor-programmer when I cut corners. Here's my 2 cents now:

- Some of this is the coding equivalent of "6 rules for financial freedom" or "6 ways to find your dream soulmate". Generic advice that doesn't reflect highly nuanced reality.

- These rules are guidelines at best. There are justifiable reasons to break them; which I do often. Albeit this requires experience (and dare I say, wisdom). For example, refactoring code into a separate function levies a cost (of indirection) on the reader. Therefore copy-paste is sometimes fine.

- Clode "cleanliness" is a moving target. For a coder's mental health and value proposition for his project, he/she should know what code can afford to stay dirty.

PS: I love Jonathan Blow's opinions on coding/programming. Here are a few: https://www.youtube.com/watch?v=21JlBOxgGwY https://www.youtube.com/watch?v=ubWB_ResHwM https://www.youtube.com/watch?v=KcP1fXQv0iU

Re:Show HN: AutoHotkey for Linux on Tuesday August 30, 2022 @06:59PM (#32656261)
AHK is excellent; created a fishing bot during the hardcore WoW raiding days (Stonescale eel for Flask of Titans, anyone?)
Re:Ask HN: What is something exciting you're working on? on Monday February 21, 2022 @04:21PM (#30420781)
I started my own bioinformatics+AI services firm that specializes in cell-type specific biomarker discovery and immune-repertoire profiling (i.e. we use single-cell and NGS technologies). I have developed a pipeline that integrates/automates state-of-the-art algorithms, which I use to serve clients (biotech and academic labs).

My clients are mostly local (i.e. Switzerland) acquired through word-of-mouth. Client acquisition is a challenge because I have to juggle sales and execution. However I am super excited to be in this field because I believe this is exactly what precision medicine is.

The company is called YugaCell (http://www.yugacell.com)

My first job out of college was at a J2ME mobile startup (circa ~2005). Startup was the baby of a rich Arab, and I was the first actual technical hire in the team (the prototype was outsourced). I hired 3 engineers within the first month. A couple weeks into the project, I realised that one of the juniors was a bozo at programming and I had made a severe hiring mistake. The guy spent time re-writing Java classes as objects, making superfluous inheritance hierarchies, installing and re-installed the J2ME emulator, etc. I would have to fire the guy soon and explain it to my Arab boss ...

Fortunately, new hire was sending sexually explicit SMSes to the cute Filipino receptionist. Arab boss threw him out the next day.

Re:Radian: A 21 century R console on Thursday July 01, 2021 @10:34PM (#27707327)
R is overwhelmingly used in bioinformatics. There is nothing quite like bioconductor. Most new tools/methods (for ex, in the scRNA-seq) release R packages first.
Re:Fierce Nerds on Tuesday May 18, 2021 @10:22AM (#27194942)
> The bad news is that if it's not exercised, your fierceness will turn to bitterness, and you will become an intellectual playground bully: the grumpy sysadmin, the forum troll, the hater, the shooter down of new ideas.

I like this.

I tried to sign up for the free trial but I don't want enter my CC details. Can I just do test a free-trial?