gusennan

Vegetarian here. I like Beyond products, such as their chorizo, and eat them all the time. I don’t eat animals not because I’m trying to “eat healthy”, but because I’m trying to opt out participating in a system that is brutally cruel to sentient beings.

I bought an EV on December 18. On December 19 I took my family on a 2400 mile road trip up the US east coast and Canada, with multiple days of all day driving.

It worked out fine! Driving the car was also much more enjoyable than driving our loud gas car. Yes, we stopped to recharge every few hours, but I also needed to give my mental focus a break from driving, too.

an instructor’s solo sign off is only valid for 90 days in the US, and there are a bunch of restrictions as to what a pilot is operating under the instructor’s sign off can do.

They solved an open challenge problem, Protein Structure Prediction, with AlphaFold, which has been nothing short of revolutionary in the structural biology and biochemistry fields. I do scientific research in these fields and the capabilities AlphaFold provides are used now everywhere.

I am in a lab that does similar research on resistance to cancer therapeutics but using different computational modeling methods. This is really interesting stuff, as kinetics as a method of resistance has been something that we know is important from a biological perspective but hasn't yet been incorporated much in resistance modeling.

I just turned 35 and my situation is very similar to yours, with the exception being that I am married. Partners and family do give one's life a lot of meaning. That said, I'm glad you asked this question, as these topics have been occupying much of my thinking lately as well. I don't have the solution, but just want to let you know others feel the same as you (as you have probably already seen in the comments!)

Early evidence seems to show that AlphaFold has trouble with single point mutations that change a protein's shape, so completely de-novo proteins will be a challenge:

https://www.nature.com/articles/s41594-021-00714-2

That's true.

I only really started liking .NET when I stopped using visual studio a few years ago.

This is my experience as well building and running .NET core stuff on Arch Linux all the time. You just have to know what you're doing, and the Microsoft documentation doesn't make it easy to take the minimalist route.

Microsoft could do a much better job onboarding new developers.

I get a flu shot every year, getting boosters of these vaccines doesn't bother me at all. There will be other vaccine "implementations" (Novavax, for example) that will get better over time.

I agree it's good news that the project complied with the original court order from 2018, which was to block the works on German IP addresses that are still under German copyright law. Why would American copyright law apply in Germany? It's a bit disingenous of Project G that, instead of blocking access to just these books in Germany, they blocked access to the all the books. That was project G's, and not the German court's, decision. I'm glad they've changed their minds.