fasa99

>customers with respected ended quite a while ago (except during COVID of course. But that's mostly over).

I definitely didn't feel respected during covid. There was a mask rule, standard for the time, fine. But then they give out drinks, okay. They were extremely strict, you must sip your drink and have your mask on again within less than a second. Long sips, unacceptable. Pause in your sip, unacceptable, there needs to then be two sips with an intermediate remasking. The air staff were quite 1930s Germany as far as the rigor of their enforcement of this rule. This has all the charm and beside manner of a driver laying on their horn 200ms after the red light turns green. Quite bizarre, the mask fetish, when most passengers were vaccinated and there's this huge vector of spreading the disease called touching things with pathogens on their surface aka fomites.

>I'm surprised the police doesn't have to pay for them. It's not that the tests were medically necessary. If only it were so simple. Medicine can be quite nasty politically at times, internally and externally, and these mandatory examinations are the currency of really screwing someone if that's what you want. Psych especially, part of the theme of the original catch-22 book.

A lot of the laws are at first pass related to psych - "harm to self or others". That earns you a free non-voluntary trip to the hospital. The part where it gets nasty is when words get twisted, when ulterior motives exist, when the accuser possesses some authority - such that an "unsafe to self or others" argument is put forth. Situations where the person needs help, but perhaps won't seek it out on their own, thus the state must intervene. In this narrative, our police officers said, "harm to self, drugs in digestive tract, may rupture and cause death, not willing to seek medical care for fear of losing drug transport and/or prosecution, please treat so they don't rupture"

The victim of such a crime now has a choice - pay a bunch of money to the hospital to clear the bill, or pay a bunch of money to a lawyer to get the police to pony up responsibility. It's happened to me too along the lines of "the government made big mistake and caused problems for you, you can take ownership of the false accusations, or pay a bunch of money to a lawyer to have them wiped". Often in our society there's the suffering of being a victim, then the victim tax on top of that

I set mine to Spanish and now it's nothing but Taco Bell ads

I personally don't believe any argument that says it's not feasible.

Transcribing all spoken text and sending it home, sure, not feasible.

What if we have 256 keywords, or 65536 keywords, maybe preconfigured for particular products or product classes. Some basic linear predictive coding mechanism ( you know, what powered those '80s chips Stephen Hawking style, speak and spell, etc) - very very low computational overhead. When the word is triggered, queue a message back home at the next reasonable opportunity - user id, timestamp, word. It will only take a couple bytes. It can be slipped in anywhere and obfuscated by any means by nature of being so small, data-wise, even as a watermark of some sort. By using a timestamp and waiting until the next opportunity, maybe minutes, hours, or days away, no time correlation detection is possible either.

People say big tech is ethical, fine. Maybe some ad company is sponsoring some free app or game for the phone, and slipping this in there. Now the developer can pay their rent and food costs. Maybe the ad company is then selling that data back to big tech who washes their hands of any wrongdoing. Maybe it's all legal because the fine print of the EULA allows for this.

Seems to me though this can be figured out empirically, just have a voice play something like "need to buy adult diapers" or "new tires" etc next to a device, enumerate every device, look for ads on whatever very specific topic, minding along the way to tell nobody and never enter it in any internet-connected keyboard.

I'm a big archive team fan but gotta go with the ABC acronym such as "always be collecting" or "always be capturing"

A lot of regulations are a mess. As I understand it, agriculture drones full of fertilizer are beginning to be used throughout, makes sense. And tractors run on diesel since forever. So add diesel to the fertilizer drone now you have a viable powerful weapon... unregulated. I'm sure tens of thousands of farmers have this in their pocket right now, just not their intent. Same with firearms. A pea shooter .22, highly regulated, felony charges everywhere. Now, a 50 caliber airgun? No gunpowder, not a firearm. They even make automatic airguns. Arguably with a large air supply and large ammo clip, and airgun could trounce some automatics, primarily because their barrels won't overheat, they might overcool though because physics of expanding gasses. And yet the humble .22 is the highly regulated one.

Some governments and regulators attempt to enumerate every possible conceivable bad thing and outlaw it. Problem is it's not enumerable, there will always be dozens of missed loopholes, which the regulations will steer people into. Parallels the warping and skewing of trying to fix an economy through proclamation versus distributed capitalism.

“We had two barrels of fertilizer, seventy-five pellets of gunpowder, five sheets of high powered C4, a salt shaker half full of nitro, and a whole galaxy of 50 cals, buckshot, slugs, tracers... and also a quart of kerosene, a quart of diesel, a case of grenades, a kilo of raw uranium and two dozen rockets. Not that we needed all that for self defense, but once you get locked into a serious explosives collection, the tendency is to push it as far as you can.”

-Osama Bin Laden

This is just the first pass. There are second pass strategies that could improve and are even more insidious: - review your generated CV pre-submission, make changes, do this a lot. Eventually you'll have a training set to fine-tune the model - throw 100-200 CVs at a job and see what sticks. That's your training set for that job. Now you have tuned the hiring manager's preferences. Follow up with your actual CV. Side benefit is it will jam up other candidates.

An arms race is afoot

For sure, a lot of hard work and energy went into this project. Some say that if Boeing had that kind of energy, their planes might even fly!

For what it's worth, back in the day (a few years ago, before the LLM boom a few years) I found on a similar sized vector database (gensim / doc2vec), it's possible to just brute force a vector search e.g. with SSE or AVX type instructions. You can code it in C and have a python API. Your data appears to be a few gigs so that's feasible for realtime CPU brute force, <200 ms

This is in accordance with Gilette's law, which is that the number of headlights on a high end pickup truck shall be equal to the number of blades on a high end razor

WAIT ... Hole up... what have we here: https://www.nccn.org/compendia-templates/compendia/nccn-comp...

TLDR: The NCCN surely has a clean pretty database of these algorithms. They output these junky pdfs for free. Want cleaner "templates" data? Pay the toll please.

What we have here is a walled garden. Want the treatment algorithm? Here muck through this huge disaster of 999 page pdfs. Oh you want the underlying data? Well, well, it's going to cost you.

What we have here is not so much different than the paywalls of an academic journal. Some company running a core service to an altruistic industry and skimming a price. OP is just writing an algorithm to unskim it. And nobody can really use it without making the thing bulletproof lest a physician mistreat a cancer.

To my sentiment this is yet another unethical topic in healthcare. These clunky algorithms, if a physician uses them, slows the process and introduces a potential source of error, ultimately harming patients. Harming patients for increased revenue. The physicians writing and maintaining the guidelines look the other way given they get a paycheck off it, plus the prestige of it all, similar to some scenarios in medicine itself.

The natural thing to do is crack open the database and let algorithms utilize it. This whole thing of dumping data in an obstruse and machine-challenging format, then a rube goldberg machine to reverse the transformation, it's not right.

Anyway I mention this because there seems to be a thought of "these pdfs are messy lets clean them" without looking at what's really going on here.

Well we do take actions i.e. https://www.unmc.edu/healthsecurity/transmission/2024/07/10/... Literally killing millions of livestock to isolate the spread. Not to say there aren't better ways. Life finds a way. It's hard.

Exactly. That's what I think it is, government secrecy as their standard operating procedure. When unsure, don't say anything. After all, disclosing the public includes adversaries also knowing.

It seems to me what's happening is a "Streisand Effect" where the whole attitude of "go away, nothing to see here" is in fact maximizing attention and defeating the purpose of hiding this away.

If it were me I'd put a band-aid on a drone, fly it to a person, and say, "we are testing military capabilities to render first aid to our soldiers" or something similar. It's not a lie, it's good optics, adversaries can worry about it... then put whatever it is on ice for a while until the heat dies down

Not just temperature but I remember it as the hormone control center.

You have hormone release factories such as the liver, the adrenals, and the sex organs such as ovaries and testisatchels

Then you have a feedback control loop, the manager of these factories, the pituitary. But we're not done yet! The hypothalamus in fact is another feedback loop controlling the pituitaries which controls the hormones. So in fact with things like transgender it is things like the hypothalamus-pituitary link that is interfered with to shut down endogenous sex hormone production

As such the hypothalamus seems a physiometabolic control center. This makes me think the mechanism is less to do with a direct pathway and perhaps is more indirect

It's a frying pan or the fire situation. The frying pan is government healthcare. The collective US thinks the government run program is a garbage fire. Obvious reasons are that (1) it's really hard to fire bad employees government wise since employment is seen as a right and (2) it's really hard to get anything done since people think of 9999 ways to "be nice" as rights. Then, clearly for-profit institutions are also a garbage fire since they make that extra 10% revenue off of unnecessary suffering.

There is a great counterexample that is Kaiser. They are a private health insurance org that provides massive savings by simultaneously also running a network of hospitals and outpatient facilities. Notably they are not-for-profit. So that's perhaps what we're shooting for "all the goodwill of government, without the mucuousy bureaucratic slop in any government institution"

If only all the private sector orgs were Kaiser, not for profit and for the well being of humanity. Kaisers of the world are a flash in the pan, "don't be evil" googles only to become "be evil" googles.

I would simply recommend to look at how Singapore does things and copy that, after all, that's what China did and look how well they have done economically.

The general intent of the jury is to ask, "do you think they broke the law or not" and it's a jury of your peers, from your community, so it's seen as super fair.

On one extreme the jury carefully reviews the law as written and makes a judgement focused on the law. Whether they agree or disagree with the law itself is inconsequential, they must apply it.

On the other extreme (jury nullification) the jury might ignore the law and decide for themselves, then and there, what is right and what is wrong.

In many jurisdictions the jury is encouraged to adhere to the law as written, in some it is "illegal" for the jury to willfully ignore the law but there is no punishment for doing so. The concept of "Jury Nullification" is meant to be a checks & balances if some law exists that is insane or unreasonable or would be morally bankrupt to apply in a particular situation, extreme cases. So the pressure to not apply jury nullification in general is because if it were used in every case, not extreme cases, literally the jury then becomes the congress, the makers of law, and of course everything becomes kind of random and unfair depending on whatever jury you got.

This is also how the human brain works. A young babby will have something more similar to a fully connected network. Versus a Biden type elderly brain will be more of a sparse minimally connected feed forward net. The question is (1) can this be adjusted dynamically in silico and (2) if we succeed in that, does fine-tuning still work?

My wife went through that at one of the FANG companies. Many years ago. At least in her case, 100% true. Many years later the PIP (which she survived) would come up, blocking her from promotions. People who witnessed the PIP still remained and still had thoughts about it, many years later.

I will also mention talk of managers getting PIPped, she reports that indeed her manager got PIPed by the director above.

The ugly part of this is there are bad managers and bad employees so we don't know what each situation is. Or sometimes both parties are decent people but their personalities each have one too many spikes that sometimes mesh super well with people, sometimes mesh poorly.

I agree the ideal manager who is a good communicator with a genuinely incompetent employee ought to make a soft touch. If they're really bad, ideally let them know they can look for a job if they wish, offer a neutral recommendation, etc. Let them know a PIP might be coming etc since legal basis must be covered.

Problem with a poor manager, even with a soft touch, is maybe their expectations actually are bad (especially a pointy haired boss who doesn't have a conception of the labor needed). Maybe they have OCD and see all work as bad, in the same way someone might consider Scarlett Johansen extremely ugly because of that one single freckle ruining the whole thing. I've seen this too. That's all to say if a manager comes in with the sweetest gentlest informal approach and complains to Scarlett Johansen about how awful the freckle is, well, even the soft touch won't help much there.

I would imagine in most real world cases we can see both, and we can see mixes, where it's a so-so employee who might be great under a strong manager, but is weaker under a OCD manager who puts the magnifying glass on the weaknesses. And of course sometimes managers will put the magnifying glass on the weaknesses because they want to eliminate this employee for various external reasons.

bro animals can be vengeful see-

https://www.fox26houston.com/news/elephant-kills-indian-woma...

that, and cats, cats can be very vengeful creatures

I have, happens around 6 AM. They get all the generators started up, power tools and full power. All the heavy machinery at full throttle. A cacaphonous 6AM salute to the internal combustion engine. Old Zeke fills his truckbed full of rusty nails and drives aggressively around the neighborhood dropping this way and that. Well, not old Zeke nowadays, more like Senor Ramirez Carloz Gonzalez.

Question is, if it's 6 AM at a construction site, and nobody is around to hear it, do they make any noise?

As someone whose pronouns are C-programmer/vim, I feel unsafe.

My living nightmare would be to develop highly verbose Java programs in an editor with 999 gorillion different "modes" with seemingly random names.

"oh, you're making an singletonfactoryfacade in Treesat-19 mode, you'll need to be using CCC-mode, treesat-19 mode is for factoryencapsulationfactory patterns"

Generally I think modeling in the computer without proper detail in measurements and geometry is error prone. I will normally capture a 3D point cloud (can use a Kinect for this) and perform a geometry scaling, then use AI to map it into 3D surfaces compatible with CAD. This will take 1-2 days to model. Then I manually model all the elements in minute and exactly detail. Finally, after all the work is done, I assess the coloring of the cabinets to see how I feel about green vs. chartreuse paint, on a high-end monitor typically used by radiologists to assess human disease. Some people ask why not just hold a color ribbon up to it to get an idea, I say that's a waste of time, not enough.

It's bad, very bad, apocalyptically end-of-the world so. The oceans will rise over 19 miles above their current level. Weather will be come drastically chaotic, one day there will be 100 feet of snow falling in an epic blizzard, the next, 200 degrees farenheit could cook an egg. The world will end right now.

We need to reduce the population by 99.9% and stop all oil pumping full stop, stop all nuclear power, it will be painful but it's better than the alternative, we are the custodians of the environment and we need to treat it as more sacred than human life, this is what I feel and I'm an authority so you should listen to me.

It's always braggable to be able to do that more than another language, but I'm not sure how mainstream or common it is to have the use case of requiring numerical manipulation at the scale of number of molecules in the universe

I do wonder how this pertains to "blast processing" in the original Sega Genesis

Some say it was a temporal distortion field around the 68000 increasing clock speed by 900%

Some say it was the code name for programmers working 140 instead of 80 hours a week writing assembly.

Some say it is something to do with streaming realtime pixel data to the graphics chip for high-color graphical image rendering

If you ask me, though, time distortion

It's deeper than just weights because the topic is biological.

In the old days of genomics there were massive patent wars. First, the human genome project itself. Craig Venter got massive funding to sequence the human genome with the understanding he'd patent all the genes. So there was a space race of sorts where the private sector sought to beat him - lead by Francis Collins now head of the NIH. It came out a tie (or that's what they called it), Bill Clinton brought them both on a stage and said "great job! also genes aren't patentable!"

Then a whole stink arose around Myriad Genetics who patented a BRCA test. Now that's a bigtime gene far as cancer goes see: Angelina Jolie. Then in 2013 the supreme court ruled genes cannot be patented.

So what is alphafold 3? Is it a ground truth of which protein interacts with what? In which case it seems not patentable. Or is it a method, or algorithm, to estimate protein interactions? That's more grey area. Idk. If google wanted to monetize it proper they'd probably keep it as an internal black project and cook up pharma collabs and such. But they've made it public(ish). Still a long way to go, or at least some more steps. If we say Protein A interacts with Protein B, we then have to ask whether they're expressed in the same cell, which itself is not enough! Most bio measurements are in big batches of millions of cells. It has to be same cell at the same time. So if our batch is a million cells w/ protein A, a million cells w/ protein B, then it looks like both are "on" in our batch of 2 million cells. But the truth is more nuanced. And then even then, other considerations such as post translational modifications and which cellular compartment these proteins reside in.

of course the famous AWK as well

Man ain't nothing one disease. Look at COVID. Why did the vaccine fail. Not one disease. Population variation of the virus. blah blah. Renal failure - shades of grey, shades of causes. Heart failure - shades of grey, shades of failure. High blood pressure - how high? Why? Who says it's high?

You see? Your point is unremarkable in the face of all diseases.

The handwavey reddit tier explanation you're shooting for is that cancer is genetically unique in each person. Which really is a gross oversimplification, there are non-unique genetic components of that are common themes across many cancers- TP53, PIK3CA, BRCA, KRAS, MSH, etc etc.

So such an explanation is lame because if there's all these common genes than it seems curable - which it would be if that were the long and short of it. Reason it's hard to cure is half those genes I name jack up replication machinery so it makes errors all the time. So now our cancer is not a genetically unique cancer, it's billions of genetically unique cells in one body, always mutating. Now it's not drug developer versus cancer, it's drug developer vs Charles Darwin, evolution. And of course there is a solution for that. Immunotherapy, or as the link shows, immunostimulation. Because the immune system also uses evolution / artificial selection!