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codytruscott

Screening ‘test’ vs diagnostic ‘test’ is an important concept.

Screening tests are designed for sensitivity — false positives are expected and identify who would benefit from additional diagnostic tool and procedures.

Re:Gene therapy restored hearing in deaf patients on Wednesday July 02, 2025 @05:32PM (#44449075)
Rather than 23andMe, Ancestry ($50-$100) etc => imputation, broad clinical labs offers exome + genome blended for $120.

https://usegalaxy.org is pretty remarkable and provides access to a ton of open source bioinformatics tools + compute to process the files.

I really think the $1200 20x pacbio from broad is worth it if you are going to make it serious hobby.

Re:Gene therapy restored hearing in deaf patients on Wednesday July 02, 2025 @04:26PM (#44448435)
Whole Genome Sequencing is affordable now. I’d suggest a 20x hifi long read from broad clinical labs for $1200 or so. Use opencravet to dig into the results. They just posted a webinar for personal analysis https://wse.zoom.us/webinar/register/WN_-VvYJ8FKRcGaKCQtLFrU...

Franklin by genoox is a slicker and possibly more approachable product depending on your interface preferences.

Genetic research — due to the number and subtly of variants — is ripe for citizen science in my opinion.

Re:Bioaccumulation of Microplastics in Decedent Human Brains on Wednesday August 21, 2024 @09:53PM (#41315982)
Seems like a reasonable possibility considering the notable jump in PE in the kidneys.
Re:Bioaccumulation of Microplastics in Decedent Human Brains on Wednesday August 21, 2024 @09:47PM (#41315936)
Reasonably significant transition to PEX piping for domestic water supply starting in 2004 following a surge in copper pipe pricing.
Re:Bellingham, Washington gets a new makerspace: The Foundry on Friday September 12, 2014 @05:19AM (#8307223)
Let this be a lesson to folks. Sales matters. The clear disdain, lack of respect, or perhaps just disinterest for building a solid sales process/pipeline at makerhaus led to it's demise.
Re:Seattle votes for $15 minimum wage on Tuesday June 03, 2014 @05:04AM (#7838847)
This is bogus & unsourced. The minimum wage in Seatac was $9.19/hr in 2013, not $7.
Re:College or self-study? Is a good school important? on Monday May 26, 2014 @02:42AM (#7798931)
Goto the best school in your country.