bsmrea

Both the Bear Stearns and Washington Mutual purchases were during the Bush administration.

Do you make the same salary as you would in the Bay Area or did you have to offer a discount?

Here are a few mutation databases, in addition to the ones already mentioned:

http://cancer.sanger.ac.uk/cosmic https://dcc.icgc.org/

This is a nice analogy to genome assembly and there are some technologies that try to label DNA before sequencing to aid reconstruction. The one that comes to mind when reading your post is the 10X Genomics system, which acts as a preprocessor before Illumina sequencing. The idea is that you can introduce nucleotide tags into the DNA molecule(s) before sequencing, then use the tags to figure out what short reads came from the same DNA fragment later on. There is a nice video on 10X's website explaining how this works and how it helps:

https://www.10xgenomics.com/technology/

Just to be clear this isn't my analysis - and yes most of the errors here are due to indels.

The error rate of recent nanopore data is much less than 30%. See here for a recent benchmark: https://github.com/rrwick/Basecalling-comparison

This problem is called sequence assembly or genome assembly, not sequence alignment (which is a related problem).