armedgorillas

I'm not quite following how the relationship between microbiome science and an infection of the microbiome is minimal.

But more to your point, using the mg data from their "healthy" population along with the open-label data in the literature seems like a good way to construct RCTs, no? Data from open label studies isn't speculative... it's just not phase 3.

In case you're curious, here are two papers on UC: https://www.ncbi.nlm.nih.gov/pubmed/28214091 and https://www.ncbi.nlm.nih.gov/pubmed/29052237

The FDA disagrees with you (about the role of the microbiome -- I doubt they have an official opinion on biotech funding). C. Diff. is probably the biggest indication with multiple clinical trials going on to demonstrate the efficacy of full-spectrum fecal microbiota transplants as a therapeutic. Besides that, check out the work of the Allegretti or Borody labs for more human studies about the role of the microbiome in various metabolomic, developmental, and autoimmune diseases.