abhikshah

ML is fairly common in genomics, but for identifying predictive variables for cancer status, it's difficult. The training set is a matrix where rows are people (where some have cancer and some don't) and columns are genomic features (mutation, methylation, etc). You can easily have hundreds of thousands of features but getting even a thousand cancer patients enrolled in a study and sequenced is expensive and slow.

So, even though there are many "AI in biotech" companies out there, for predicting cancer status, most eventually end up hand crafting a small number of features based on extensive knowledge of cancer biology. The ML model tends to be simple and far less important than the features.

Your intuition here is great.

1. Nano bots -- no idea; outside my wheelhouse.

2. Liquid Biopsy -- many companies are working on diagnostic tests to detect cancer early, monitor treatment, detect recurrence, etc. Some of these products are already available but most are in R&D phase.

3. Immuno-Oncology -- the most promising development in cancer treatment in a long time. Successful tumors evade the immune system by essentially hiding themselves. Many companies are working on treatments to assist immune system in different ways. Some products have been in the market for a while now and have been pretty successful.

Wow, that's an elegant solution!

I also have a difficult time reading large numbers without commas. Because I use Alfred (mac command launcher) quite a bit, I wrote up a simple workflow to re-display selected numbers with commas. Not as universal as the font-based solution but might be useful to some:

https://github.com/abhik/tres-commas

The point is to end the constraint that only astronauts can go to space, to open it up to everyone.

> For to accurately and repeatably describe positions

IMO, for most use cases, you don't need to describe positions; you provide something analogous to a SQL where clause.

Most querying in cell biology appears to content-based rather than coordinate-based. "drive down this artery 1000 cells" is not useful because your target might be 1010 cells down next week. Instead, you might say "drive down this artery until you find a cell with this particular receptor on the cell wall." Rather than keeping track of how many cells you've passed, you randomly bounce around the artery until you bind to a compatible receptor.

Actually, a 'debug' or 'dry-run' mode that simply prints out the git commands without running them would be useful for all kinds of users. Newbies can learn from it and pros can make sure that the commands are going to do what they expect it to. With git, I know what each command does but my concern with legit (and similar) is that the higher level commands might not do exactly what I think based on their name/description.

Racial disparity doesn't just result from racism or "like preferring like". There are many institutional and structural issues that are partially causal and a frank discussion could help uncover them as they relate to the startup world. Sadly, frank discussion of race is very difficult in this country.

Btw, I do agree that the valley is very meritocratic so I don't think racism is a big factor.

Space might be an issue but it's also strategic. I need the higher-resolution screens and have bought (and will continue to buy) the 15" versions even though I don't really need the better CPU or GPU. I'm sure there are many others like me who grudgingly or not will fork over the extra cash.

I'm getting the 15" for just that reason. The extra weight is worth having two vim buffers side by side.

The table needs context. How much could the same person make in private industry for a similar job?

I remember people asking the same kinds of questions when Wolfram Alpha was released. Alpha and Watson work in very constrained spaces and transferring their success to general search is very much non-trivial. So, no Watson will not make a dent in Google.. It'll be a very helpful tool in specialized areas but scaling it out is not a matter of a year or two..

I agree but my conclusion based on this is that, for the foreseeable future, we'll need hybrid systems that can merge expert knowledge with machine learning.

In the coming weeks there will be a lot of hand-wringing about Watson's performance on Jeopardy and what it means for humanity and jobs and so on.. I think it's important to remember that the last mile in many tasks will still require humans and that AI should be seen more as human augmentation rather than replacement.

The Personal Genome Project [personalgenomes.org] is aiming to recruit 100,000 people to publicly release their DNA sequence and medical data. The website currently has phenotype and medical history data and genotyping data for the first ten participants who are all well-known scientist.

Interestingly, one of the cofounders is Dileep George, previously the CTO and cofounder of Numenta.

I would say "Brain-inspired". As I see it, Numenta's model (as of about a year ago) is based on (1) the hierarchal organization of neurons, (2) the presence of feedback loops in neural architectures and (3) the importance of temporal processing even for static scenes. This doesn't include any intracellular details nor any of the larger and/or specialized brain structures.

Instant app compatibility? Wouldn't they also need to provide the same set of APIs that Android provides?

There have been congressional hearings regarding Ticketmaster's monopoly. Not sure why nothing came out of them.

http://www.indiegogo.com/ is getting good press lately but I don't have direct experience using them.

FYI: http://mygengo.com/ provides a platform for crowd-sourced translations. Of course, the market is big enough for multiple players..

infochimps.com

I agree that AT&T should not have "personal privacy" rights but the reasoning described in the article seems very odd to me (IANAL, obviously). To me, "personal" and "person" seem obviously related. And more importantly, the fact that the outcome of the case hinges on this grammatical detail seems silly. But, I suppose until corporate personhood is repealed or overturned, this is the only way to restrict corporate overreach.

I interpreted his quote differently. The difference is not in abstract vs concrete but in open vs closed.

Presumably, the researchers building open-source EMR systems do talk to patients and hospitals rather than building abstract software in a void. They don't, however, need to worry about profitability and would be more free to integrate with other systems and not try to create lock-in.

I'm also in a similar situation. The name I'd like for my webapp is taken and i'm considering hq.com or app.com. Or would it be better to use a .net or .biz?

Shared hosting at webfaction. For the app (medical documents workflow) and scale (for small company, < 50 employees) webfaction is great. I could probably find a cheaper host but being able to work with support staff who actually understand coding and syadmin work is worth the slight extra cost.

Bringing some game mechanics like this is a great idea. The rewards of doing work are usually distant but an index like you describe makes it apparent immediately..

Looks interesting, will definitely have to play with it. How does performance compare with cut,grep and friends on large files?

In "about:flags" on Chromium (10.0.613.0 on OSX) there's an option to enable expose-style viewing of tabs by swiping three fingers down.. which is really convenient because swiping 4 fingers down is the default on Macs to invoke expose.

"couchsurfing" is a worldwide community of people that is quite different from just going from couch to couch.

I believe there's another lesson here: the importance of failing early. Ed didn't spend a frustrating career before quitting politics or fours years before quitting math. It can often be far easier to continue doing something you don't truly enjoy than to quit and try something else.

Looked through the blog but don't have time for the videos. From my perspective (computational systems biology), it looks like an amalgamation of ideas surrounding Complex Adaptive Systems and Statistical Machine Learning. And I really do like the way the material is presented. But, without a single equation, algorithm, result or comparison with existing methods, it's hard to tell whether there's any technical substance here.