aBioGuy

It is SO hard to make things (as someone who also dabbles in wood). It looks awesome, has exactly the light patterns you want, and doesn't make an audible buzz - awesome!

And you've also learned something about aluminum extrusions!

Glad you got it done!

I'm very confused at the aluminum frame - it would have been far easier to just buy a $5 (?) piece of pine (or equivalent softwood) to make the back frame. The pine can also be customized with a handsaw. I guess I would have rather spent more money on the visible part (walnut planks instead of a used countertop?) than the invisible part.

Another anecdote (where it came from I do not remember) stuck in my brain was that Watterson's editor called him one day to tell him that STEVEN SPIELBERG was on the phone to talk with him about a Calvin and Hobbes movie. Watterson refused to take the call.

In the title "....in the APP/PS1 Mouse Model of Alzheimer’s Disease"

Given the decades of emphasis on clearing / preventing amyloids I would be fairly jaded. If someone (biotech) wants to spend $$$ chasing this down, good on them.

But a paper curing a mouse model of a human neurological disease does not move the needle for someone with or watching someone suffer from this disease.

The M4 MacBook Air (16gb, 1TB) retailed for $1400 (https://www.bhphotovideo.com/c/product/1884084-REG/apple_mba...).

The M5 equivalent is now $1300. 1TB requires the CPU upgrade.

I would like to point out (as I have seen this confused by many non-scientists) that the NIH (National Library of Medicine) provides a service called "PubMed" which collates peer-reviewed (and many pre-print) scientific papers into one database / website. This particular paper (like 99% of the papers on PubMed) was not published by a NIH scientist or by the NIH itself.

Vehicular gas infrastructure is near 100 years of development and still has some edge cases.

EV charging infrastructure is at about 10 years.

Well a Tern GSD has a max carry weight of 379 lbs and a max speed of 20 mph. Only needs a 0.5 kWh battery too. Has infinite range, depending on your fitness.

No has mentioned that the initial assertion is incorrect? The US Government sent troops to remove native inhabitants. Then they gave the land away. Having an army clear the land ahead of time makes a lot of homesteading possible.

I remember when I moved to DC many years ago we drove to an art exhibit (in an empty building way away from the metro). There was a guy walking up and down the road saying "$5 to park!" I paid him and in the elevator an older woman smugly told me "It's free to park here!" I told her "I know, I'm paying for him to not break MY window." The look on her face....

Unpopular (?) opinion: don't worry about theft. If you are making developer-money then a $1000-$3000 bike is a trivial amount of money. Just use a cafe-lock with a sturdy chain and go about your life. It gets stolen? Buy a new one. Seems silly to be hesitant on a eBike because of a theoretical concern. Finding an environment where you are reasonably safe from getting murdered by a vehicle should be your primary concern. Everything else is just noise.

The cheapest and simplest strategy is to buy several external drives and leave them at work / someone else's house.

I thought that held the coaster AOL sent everyone in the mail.

Depending on where you live, you can cargo bike with your kids. If you check out the cargo bike forums there are always posts on how to attach baby seats to a bakfiets and such. I've got two kids and my ecargo-bike replaces about 20 car drives a week.

Furthermore, scientific computing often (usually?) involves trainees. It can difficult to train people when small mistakes can have five figure bills.

If you make it pleasant to ride a bike - people will do it.

Where I live, there is an off-street bike path that was completed about 10 years ago. Since then many new businesses have opened along the path. The economic impact of pulling people OUT OF A CAR and INTO THEIR environment is perhaps under-appreciated.

The e-bike (pre COVID) would do about 2-3 24 mile trips a week. Plus the local trips. The other 1-2 days were a regular bike. That's a lot of rush hour miles removed from the road.

Well the car has about 1000 miles in the same time frame. A second (non electric) bike has about 1500 miles. More importantly I was seriously considering replacing the car (it is quite old) but with the cargo bike the car gets used so infrequently now it doesn't seem worth it. Plus if the car does go down we can replace it at a leisurely pace.

Tern GSD

I have two little kids. I also own an electric cargo bike. It has replaced over 2,000 car miles in the past year. I can bike to the grocery store, with two kids, and come back with a week's worth of groceries.

Doesn't this suggest that cities should continue to build out their bike infrastructure? You can't get high bike use without protected lanes / etc.

It's popular with scientists (genomics) for making web portals to interactively share data / plots / analyses.

The number of users to such sites is (often) measured in dozens of people per day.

I'm a bioinformatician, not a web developer, and Shiny has been a great tool to share my work with something I'm already familiar with (R).

(I'd share a site I've made with Shiny but I'm pretty certain it'd explode with hundreds of concurrent visitors - but that's OK! I get dozens of visitors a day and don't expect any more)

After I requested work buy me a tricked out MacBook (which I received literally last week), I saw the rumors that Apple would soon update their MacBook line. I was mentally preparing to be gutted when Apple would update the MacBook with two fullspeed USB-C ports and Touch ID....instead they cancel it!

The Air is barely more compact than the Pro (look up the specs, it is a bit thinner on one side and is 0.25 pounds lighter).

The MacBook is a true ultraportable laptop (it is 0.75 pounds lighter than the Air) - sad that Apple doesn't sell one now.

This is a nice intro. For a good collection of "worked out" "pipelines" to analyze different kinds of genomic data types (RNA-seq, ChIP-seq) in the R environment (the concepts are universal, even if you don't R), take a look at Bioconductor:

https://www.bioconductor.org/packages/release/BiocViews.html...

Yeah, that's why we subscribe. Digitally renting a movie is crazy stupid for busy parents of young children. It takes us 2-3 days to watch a movie (in the ~40 minute chunks we have each night). Digital rentals force you to finish watching a movie within 24-48 hours...

This was published yesterday (title says 2012).

A 'gene' is a distinct set of DNA nucleotides. What changed were 7% of his gene's expression levels, across time. Which is not a particularly remarkable finding. If approximately the same 7% of genes changed for most astronauts after x months in space, then that would be more interesting. The 7% change is a n of 1 experiment.

Agreed. I'm more interested in the cheap semi-quick data storage ($0.01 / GB / month) than any of the workflows they offer. I'm also not interested in learning a new syntax to replace what I can do with UNIX / python / R (ggplot2) already.