YHK

Yeah I saw that. It is a bummer, I want to take a look at it now. I will try to ask around to see what is happening there.

I will admit, I am no patent expert. To my knowledge, you can patent the process, the molecule, the use of the molecule. I don't know exactly why they are all anonymous on 4 thieves vinegar, I assume it was because of patent stuff. It might be for other reasons. I would believe that showing instruction to produce a patented molecule would be an issue. (maybe not, I don't know) For insulin, I can assure you that there are patent for processes. Quite annoying.

I forgot to mention it, but there is also FDA requirement to how we disclose the protocol. Usually it is patented process, so we are looking to see how we should do it to not create issue for the FDA validation. Other volunteer are working on this side, not me. I am a simple biochemist, those things are two complicated for me.

The four thieves vinegar is doing something like that (https://fourthievesvinegar.org/) They work also on patented molecules and try to reverse engineer proces, and then publish it. (which makes it illegal, so they are anonymous) I don't know how many molecules they published though.

It is a risk, I agree. I can assure you that there is work done in the lab, and that we plan to publish it, one way or another. I personally think that bioRxiv can be perfect to do a fast publication.

Thank you. This is exactly what we are trying to do. It is difficult for us to get rid of the mad scientist label.

We have a team in fact that evaluate the FDA requirement and looking at what would be the best way to do it.

Also, Open IP means for us that we will share the modified strains which are optimized for the expression of the insulin, and ideally, we will be able to provide scientific knowledge and resources to help the creation of local manufacturing plant.

There is one plant for each big pharma. Eli lilly is in indianapolis. https://www.industryweek.com/expansion-management/strategic-... Novo Nordisk in Raleigh. https://www.pharmaceutical-technology.com/projects/novonordi...

This is not really decentralized and is really risky, for obvious reason. https://www.ibj.com/articles/eli-lilly-asking-employees-to-w...

Hi, I am one of the scientists working on the project. We had a lot of discussion on the project about defensive strategies to avoid any issue, since we are dealing with a massive industry. We don't have a definitive protocol yet, so this is why it is not publish. But if you want more details, I would be happy to answer your questions.