The_rationalist
The_rationalist on Hacker News
Re:GraalVM 22.1: Developer experience improvements, Apple Silicon buil...
on Tuesday April 26, 2022 @12:38PM (#31169627)
yes shopify runs on truffleruby. It is the fastest ruby VM by far and can seamlessly call state of the art Java libraries.
GraalVM is the VM to rule them all and unify currently incompatible billions of dollars libraries ecosystems.
Despite being the computer science breakthrough of the decade, people are not getting it yet.
Re:Why is inflammation a dangerous necessity?
on Thursday April 21, 2022 @09:56PM (#31117393)
I don't think doing exercise trigger an inflammatory (immune) response although I might be wrong. Either way your point stand regarding its paradoxical effect on oxidative stress.
Re:Why is inflammation a dangerous necessity?
on Thursday April 21, 2022 @06:38PM (#31116050)
An open question would be wether the baseline inflammation level could be lowered if we implemented a periodic but rarer higher inflammatory level.
So a ~flatline vs a sinusoid. It could be pharmacologically simulated.
Re:Gallium OS: a fast and lightweight Linux distro for ChromeOS devices
on Thursday April 14, 2022 @08:47AM (#31026219)
Why a dedicated distro, can't you use any distro on a chromebook?
Re:86Box: Why Not Pentium III?
on Friday April 08, 2022 @12:11PM (#30958992)
Should does not equal must. Wanting a better world with less suffering and more joy is not the same thing as imposing this world by force. A thought that should have occured to you.
Re:86Box: Why Not Pentium III?
on Friday April 08, 2022 @11:13AM (#30958119)
Well that makes pcem and x86box very niche then.. What should people actually use for emulating a recent x86 cpu like found on the PS4/PS5/xbox serie x and get good performance? Because this is where the human resources should be allocated, for enabling the support of hundreds of video games including major console exclusives
Re:86Box: Why Not Pentium III?
on Friday April 08, 2022 @09:34AM (#30956588)
I don't understand,the yuzu (switch) emulator has excellent performance and correctness. It perfectly emulate a modern ARM cpus at multiple GHz and properly emulate the Tegra Nvidia GPU.
Why would emulating x86 be so much harder, especially since you can actually use the host x86 cpu... via hardware hyoervisors e.g. https://github.com/intel/haxm
Re:ACM Opens First 50 Years Backfile
on Thursday April 07, 2022 @05:44PM (#30950717)
This is big
Re:Ask HN: Beating depression with or without anti-depressants?
on Tuesday April 05, 2022 @07:52PM (#30926668)
MAOIs are not necessarily more dangerous, they just need a low tyramine diet which is easily doable. Moreover you can significantly lower this need with a concommitant NRI.
transdermal (emsam) or selective mao-a or b don't even need a diet and are safer than SSRIs (no PSSD)
Re:Ask HN: Beating depression with or without anti-depressants?
on Tuesday April 05, 2022 @07:48PM (#30926641)
> Anti-depressants, if dosed and chosen properly, have basically no side effects
WTF is that bullshit ?
SSRIs destroy libido and possibly permanently (see r/pssd)
MAOIs have many side effects
NRIs are not effective
NDRIs can cause tinnitus.
Stims are cardiotoxic and usually not prescribed for depression.
TCAs are not an action mechanism and therefore fall in the above categories.
Atypical mechanisms are not better either.
The only ones with low side effects either cause some sedation (mirtazapine, agomelatine) or have dubious effectiveness.
The only one that stands out is moclobemide and maybe bifemelane. The latter is only available in japan. The former has low efficacy.
hence for someone that don't want side effects, only moclobemide make sense, or ultra atypical stuff that has probably low efficacy. One of the only atypical that might be potent is SAM-e but who wants to play with his DNA methylation ?
9 mebc is phototoxic unfortunately as it is very promising otherwise.
edit: it's true though that testosterone is apparently as effective as SSRIs and with less side effects.
What should be said though is that there are some great anxiolytic out there, it's just that no one knows them, e.g opipramol, emoxypine, etifoxine
Re:Pathways Language Model (PaLM): Scaling to 540B parameters
on Tuesday April 05, 2022 @11:37AM (#30920357)
if you can just get the model to answer the question you actually care about?
LOL your level of optimism is over 9000. Language models are shit, they regularly utter nonsense and have an impressive number of limitations (e.g. no continual learning). A neuro-symbolic system on the other hand can be incrementally improved upon, has continual learning/a memory, and is interpretable.
Re:Father-Son Team Solves Geometry Problem with Infinite Folds
on Tuesday April 05, 2022 @09:23AM (#30918645)
life goals
Re:Pathways Language Model (PaLM): Scaling to 540B parameters
on Monday April 04, 2022 @09:06PM (#30914055)
You could technically dynamically offload the RAM overload to disk but this would probably be too slow?
Re:Pathways Language Model (PaLM): Scaling to 540B parameters
on Monday April 04, 2022 @05:24PM (#30912111)
not a single super large language model has beaten the state of the art in the key NLP tasks (POS tag, dep tag, coreference, wsd, ner, etc)
They are always only used for higher level tasks, which is tragic.
Re:Covid spike protein induces cognitive deficit and anxiety-like beha...
on Sunday April 03, 2022 @07:00PM (#30901615)
Nearly all of it ends up in the lymph nodes near your armpit
Source needed.
Re:Lifetime Annotations for C++
on Saturday April 02, 2022 @08:50PM (#30893137)
haha C++ lifetimes go brrr
Re:Pointer Tagging for x86 Systems
on Thursday March 31, 2022 @07:16PM (#30873340)
Re:Excel 2.0 – Is there a better visual data model than a grid of cells?
on Thursday March 31, 2022 @12:26PM (#30869055)
Are you talking about this? https://www.airbase.com/ The website does a great job at making me avoid it
Re:The Uselessness of Phenylephrine
on Wednesday March 30, 2022 @03:21PM (#30859677)
btw racemic meth is legally prescribed for ADHD under the brand desoxyn, although it's probably hard to find doctors prescribing it over regular amph
Re:The Uselessness of Phenylephrine
on Wednesday March 30, 2022 @01:54PM (#30858536)
Levo-methamphetamine is a legal decongestant BTW
Re:GPT-3 can run code
on Wednesday March 30, 2022 @12:03AM (#30851378)
> A recent one can learn new concepts by simple conversation, then apply them where necessary. You can talk-train your model.
Which model? Sauce please
Re:Piece of paper quiets Intel Alder Lake stock coolers
on Tuesday March 29, 2022 @11:59PM (#30851365)
Maybe it needs some flextape
Re:Mild respiratory SARS-CoV-2 infection can cause myelin loss in the ...
on Tuesday March 29, 2022 @07:58PM (#30849896)
https://www.jneurosci.org/content/41/12/2541
Looks like there is evidence.
Also are you claiming there are no stem-cells/MSCs in the brain?
I have read multiples papers about drugs that specialize unspecialized cells into olygoendrocytes (a microglia) in the human brain. I don't see why epigenetics wouldn't allow unspecialized cells to become neurons vs glial cells.
Finally if I recall correctly, some glial cells might not act like neurons but still release neurotransmitters.
More importantly, humans should preserve their neurons by actively fighting apoptosis, e.g. by taking skq1.
And as said previously, synaptothrophics exists and are very potent.
Finally, hypermnesics are a thing.
BTW children are generally happiers/more emotional than adults. One might wonder wether this is related to neuron/synapse density
Re:Mild respiratory SARS-CoV-2 infection can cause myelin loss in the ...
on Tuesday March 29, 2022 @02:20PM (#30846441)
adults humans can have neurogenesis in specific regions https://www.frontiersin.org/articles/10.3389/fncel.2018.0044...
but the most salient thing, which is very potent is synaptogenesis, e.g magnesium l-threonate giving multiple IQ points.
Re:Mild respiratory SARS-CoV-2 infection can cause myelin loss in the ...
on Tuesday March 29, 2022 @02:17PM (#30846393)
Most of the multiple sclerosis protective compounds are generic pro-myelin drugs, e.g taking CDP-choline, melatonin megadoses, thymosin alpha 1, etc
Re:React v18.0
on Tuesday March 29, 2022 @01:14PM (#30845493)
If so, I wonder wether Vue.js automatic batching would benefit from using microtasks
Re:React v18.0
on Tuesday March 29, 2022 @12:44PM (#30844984)
What is their use case for microtasks?
Re:JEP 419: Foreign Function and Memory API
on Tuesday March 29, 2022 @12:20PM (#30844590)
Javacpp is the best ffi library of all https://github.com/bytedeco/javacpp
(except for graalvm transparent c++/java interop via sulong)
Re:Majority in Japan backs nuclear power for first time since Fukushima
on Monday March 28, 2022 @02:29PM (#30833855)
The ends justify the means and the world definitely would benefit from a pro-nuclear psy-ops