NicotineFiend
Re:Pharmacokinetics: Drug Development's Broken Stair
on Saturday September 30, 2023 @04:58PM (#37719739)
Many tricyclic antidepressants metabolized by CYP2D6 would be here, if you put the nonmetabolizers up against the rapid metabolizer, https://en.wikipedia.org/wiki/Doxepin for example.
Re:Pharmacokinetics: Drug Development's Broken Stair
on Saturday September 30, 2023 @04:44PM (#37719605)
I'm surprised the article didn't mention anything about pharmacogenetics. For example, drug-metabolizing enzyme polymorphisms can often lead to a 10+ fold difference in Cmax (or name the parameter) between a poor and an ultrarapid metabolizer of some enzyme.
Re:16-year-old arrested in England over felling of famous tree at Hadr...
on Thursday September 28, 2023 @03:07PM (#37694157)