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A wealth of epidemiological evidence demonstrates that diabetes mellitus is independently associated with the risk of developing heart failure, with the risk increasing by more than twofold in men and by more than fivefold in women.[1–3,6]
Both population studies and clinical trials have demonstrated that diabetes mellitus significantly increases the risk of recurrent hospitalisations for heart failure and the duration of hospital stay in patients with heart failure, and it is associated with a significantly higher mortality compared with those without diabetes.[11]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494155/
Cardiovascular disease remains the leading cause of death in women. Both obesity and diabetes mellitus are important independent risk factors for the development of cardiovascular disease. Obesity is the leading risk factor for type 2 diabetes. The Centers for Disease Control and Prevention report that 32% of white and 53% of black women are obese.
"FDA cannot assure the safety and efficacy of unapproved drugs" is the main excuse used in drug importation court cases.
Reference: https://www.pharmacycheckerblog.com/online-pharmacies-person...
> If you lose, your downside is not limited
Your downside is limited to the amount lent
The other aspects which you see as deal breakers that make business impossible are actually all negotiated terms to maximize the likelihood of success for both parties.